Leptin is a satiety factor in rodents. Mice unable to produce
leptin or with abnormal receptors are obese. The administration
of leptin results in weight loss with defective production.
In obesity humans, however, leptin levels are elevated, consistent
with greater fat tissue. In general, the elevated leptin levels
decrease with weight loss. It is possible this decrease in leptin
increases appetite and consequent weight regain. Leptine is limited
in its therapeutic effectiveness because obese individuals exibit
marked resistance to the appetite-reducing effects of leptin.
Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens
TW, Nyce MR, et al. Serum immunoreactive-leptin concentrations
in normal-weight and obese humans. N Engl J Med 1996;334:292-5.