Ovarian Hormones

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Estrogens estrone, estriol, beta-estradiol Adult levels stimulate ephiphyseal closure via influences on chondrocyte proliferation and function and on bone formation Facilitate deposition of fat and stimulate muscle growth Most affective in castroated male ruminants improve gain and feed conversion 10-20% Decreases protein degradation SHBG Protein Binding More binding less free estrogen Daily Human 17-beta Estradiol (E2) & Estrone (E1) Production Sex, Age Serum Concentration (pg/mL) Total Production (pg)   E1 E2   E1 E2 Children 12.0 12.5 26,520,000 16,875,000 Males, adult 38.0 37.2 97,660,000 70,308,000 Females, 41 yrs - 400.1 - 540,000,000 Also see Dietary and Environmental Estrogens. Progesterone Female hormone Prepares uterus for fertilized egg Female Hormonal Regulation Hypothalamus regulates Pituitary Pituitary regulate Overies via: Follicle-Stimulating Hormone (FSH) increases estrogen peak of estrogen stimulates LH Lutenizing Hormone (LH) increases progesterone Ovaries effects numerous organs in body including Uterus via: Estrogen estrogen dominance first half of cycle before ovulation Progesterone progesterone dominance last half of cycle after ovulation clearance of progesterone at end of month stimulates FSH (cycle repeats) Female Cycle FSH Estrogen Estrogen peak LH Progesterone Clearance Cycle Repeats Each phase is dependent upon the previous phase Female Hormonal Defects Elevated Stress Increases cortisol suppresses Pituitary function decreases Lutenizing Hormone (LH) low production of progesterone decreases Follicle-Stimulating Hormone (FSH) low production of estrogen 'Pregnenolone Steal' during chronic stress body favors Cortisol production over sex hormone production for survival increased blood sugar (see below) Blood Sugar Imbalance Increased Insulin increases Testosterone Increased Testosterone increases Insulin Problematic for female cycle Gastrointestinal issues Liver dysfunction back up of hormones Gall bladder / bile dysfunction problems if bile can't bind with hormones to be excreted Gastrointestinal (GI) dysfunction Constipation/Transit time reabsorption of hormones from large intestine Dysbiosis deficiency of healthy GI bacteria unhealthy metabolites may be reabsorbed into system Benefits of Balanced Hormones Hormones effect neurotransmitters effect mood and motivation Estrogen and Progesterone are neuroprotective help brain function and cognitive function reduced brain inflammation Balanced hormones maintain strong bones Estrogen may prevent Alzheimer's cardioprotective in women Progesterone helps regulate immune response thyroid hormones work optimally with normal progesterone cycles Diagnostics Get tested if you have hormonal symptoms Hormones Blood Sugar Adrenals GI Function