Ovarian Hormones

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Estrogens

  • estrone, estriol, beta-estradiol
  • Adult levels stimulate ephiphyseal closure
    • via influences on chondrocyte proliferation and function and on bone formation
  • Facilitate deposition of fat and stimulate muscle growth
  • Most affective in castroated male ruminants
    • improve gain and feed conversion 10-20%
  • Decreases protein degradation
  • SHBG Protein Binding
    • More binding
      • less free estrogen

Daily Human 17-beta Estradiol (E2) & Estrone (E1) Production
Sex, Age Serum Concentration (pg/mL) Total Production (pg)
  E1 E2   E1 E2
Children 12.0 12.5 26,520,000 16,875,000
Males, adult 38.0 37.2 97,660,000 70,308,000
Females, 41 yrs - 400.1 - 540,000,000

Also see Dietary and Environmental Estrogens.

Progesterone

  • Female hormone
  • Prepares uterus for fertilized egg

Female Hormonal Regulation

  • Hypothalamus regulates Pituitary
  • Pituitary regulate Overies via:
  • Ovaries effects numerous organs in body including Uterus via:
    • Estrogen
      • estrogen dominance first half of cycle before ovulation
    • Progesterone
      • progesterone dominance last half of cycle after ovulation
      • clearance of progesterone at end of month
        • stimulates FSH (cycle repeats)

Female Cycle

  • FSH
  • Estrogen
  • Estrogen peak
  • LH
  • Progesterone
  • Clearance
  • Cycle Repeats

Each phase is dependent upon the previous phase

Female Hormonal Defects

  • Elevated Stress
    • Increases cortisol
      • suppresses Pituitary function
        • decreases Lutenizing Hormone (LH)
          • low production of progesterone
        • decreases Follicle-Stimulating Hormone (FSH)
          • low production of estrogen
      • 'Pregnenolone Steal' during chronic stress
        • body favors Cortisol production
          • over sex hormone production
          • for survival
      • increased blood sugar (see below)
  • Blood Sugar Imbalance
    • Increased Insulin increases Testosterone
    • Increased Testosterone increases Insulin
    • Problematic for female cycle
  • Gastrointestinal issues
    • Liver dysfunction
      • back up of hormones
    • Gall bladder / bile dysfunction
      • problems if bile can't bind with hormones to be excreted
    • Gastrointestinal (GI) dysfunction
      • Constipation/Transit time
        • reabsorption of hormones from large intestine
      • Dysbiosis
        • deficiency of healthy GI bacteria
        • unhealthy metabolites may be reabsorbed into system

Benefits of Balanced Hormones

  • Hormones effect neurotransmitters
    • effect mood and motivation
  • Estrogen and Progesterone are neuroprotective
    • help brain function and cognitive function
    • reduced brain inflammation
  • Balanced hormones maintain strong bones
  • Estrogen
    • may prevent Alzheimer's
    • cardioprotective in women
  • Progesterone
    • helps regulate immune response
    • thyroid hormones work optimally with normal progesterone cycles

Diagnostics

Get tested if you have hormonal symptoms

  • Hormones
  • Blood Sugar
  • Adrenals
  • GI Function


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