Conditions and Medications That Make Weight Loss Difficult

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Conditions that make weight loss difficult

  •  Metabolic conditions
    • Metabolic syndrome
    • Polycystic ovarian disease
    • Cushing's disease
    • Diabetes
    • Hypothyroidism
  • Eating disorders
    • Bulimia
    • 'Carbohydrate craving' syndrome
  • Cardiovascular
    • Congestive heart failure
    • Idiopathic hypertrophic cardiomyopathy
    • Valvular disorders
  • Sleeping disorders
    • Obstructive sleep apnea
  • Upper airway resistance syndrome

Medications

Medications that may cause weight gain

  • Anticonvulsant
    • Sodium Valproate (Depakene)
  • Antidepressants
    • Tricyclic
      • can add up to 9lbs (4kg) a month
    • Lithium based
      • can add up to 2.5lbs (1.14kg) a month
    • SSRI (Selective Serotonin Reuptake Inhibitor)
      • may increase hunger
    • Potential alternative drug
      • Bupropion
  • Antihistamines
    • Cyproheptadine
    • Diphenhydramine
  • Antipsychotics
    • Clozapine
    • Haloperido
    • Neuroleptics
    • Phenothiazines
      • these drugs can add up to 5lbs (2.25kg) a week
      • ask your psychiatrist about atypical antipsychotics
  • Birth Control
    • Progestins
    • Oral contraceptives with low progesterone are less likely to cause weight gain
  • Blood Pressure Medications
    • Alpha blockers
    • Beta blockers
      • either drug can cause fatigue which may decrease activity
      • amount of weight gain vary widely
    • Methyldopa
    • Potential alternative drugs
      • ACE inhibitors
      • Calcium Channel Blockers
  • Cancer Therapy
    • Chemotherapy
      • Women with breast cancer will likely gain weight
        • may possibly slow metabolism
      • May induce early menopause
        • menopause may result in increased abdominal fat
    • Tamoxifen
      • estrogen antagonist used to treat postmenopausal breast cancer
      • may increase appetite
    • Decadron
  • Cholesterol Medication
    • Statin (HMG-CoA reductase inhibitors)
      • Statin therapy depresses fat metabolism in older individuals (Limprasertkul 2012)
        • Subject who took statins appear to have depressed fat metabolism compared to those who who had similar diets and exercise habits but did not take statins.
        • Despite elevated free fatty acid levels, Fat oxidation was significantly reduced during exercise in older subjects taking statin drugs
  • Diabetes Drugs
    • Insulin
    • Sulfonylureas
      • may induce bouts of hypoglycemia (low blood sugar) which stimulates appetite
      • can add up to 11lbs (5kg) first 3 to 12 months of treatment
    • Potential alternative drug for those with type II diabetes
      • metformin
  • Migraine Medicines
    • Valproic acid based
    • Alternative drugs
      • Most physicians are more likely to prescribe safer medications not associated with weight gain including
        • Topamax
        • Imitrix
  • Sleep Aids
    • Diphenhydramine
  • Steriod Anti-inflammatories
    • used to treat chronic inflammation or rheumatoid arthritis
    • can add up to 28lbs (13kg) on therapy
    • Potential alternative drug
      • NSAIDs (Nonsteroidal Anti-Inflammatory Drugs)
        • eg: Ibuprofen
  • Tuberculosis
    • Isoniazid (Nydrazid)

Modest dietary improvements along with an increase of physical activity may be enough to counteract the weight gain from most drugs.


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