MGF
I am in my mid 40s and have not been seeing much progress
in the gym. Someone suggested I should consider using MGF . I
looked up "MGF supplement" on Google and found alot
of information. Please let me know what you think of it.
Dr. Eric Serrano,
MD found no significant increase of growth hormone with MGF
spray in his clinical studies. Dr. Serrano has noted a significant
increase of growth hormone with 8 to 12 grams of arginine pyroglutamate
but he warns some people get nauseated.
Amino acids, such as Arginine and Orthinine may increase growth
hormone, but it has been proposed a stress to the body, such
as irritation to the gastro-intestinal system can increase growth
hormone. Interestly, workouts with only a brief rest between
sets and exercises can increase growth hormone.
The effects of growth hormone in adults seem to be more lipolytic
than anabolic. In other words, an increase of growth hormone
may burn fat more than build muscle.
Prehormones
Would you recommend 1-AD (Androgen-1). It contains 1 (5-alpha)
Androstene 3, 17 diol 100mg. The label says: "The Anabolic
platform from IDS is made up of prohormones which primarily effect
muscle tissue similar to Deca Durabolin, Anavar, or Primabolin."
 Dr
Eric Seranno, MD explains this prehormone is a very active compound,
and even though Androstene supposedly does not metabolize to
estrogen directly it will affect estrogens receptors. He suggests
you would be better of spending your money on steroids and get
better results with the same side effects. Dr. Serrano explains:
"In my clinic, 90% of the people that use prohormones
for a long time will get some type of mental problem, depression,
anxiety, something, that is why I don't recommend them".
Serrano feels the manufactures and resellers of these supplements
have been less than honest toward consumers about how well these
componds work. He does see results with some of his patients
within 6 weeks, increasing in size and strength, but after there
is no additional progress. Serrano suggests if someone insists
on using prehormones, they consider using them 6 weeks on and
three weeks off.
Dr Mauro Di Pasquale, MD also points out problems with the
use of prohormone:
- Any increase in androgen / testosterone formation decreases
testicular steroidogenesis
- possible lower testosterone levels as HPTA becomes refractory
- Estrogen and DHT formation
- Potential adverse effects
- Positive drug test
Dr. Di Pasquale concludes:
"Prehormones are too big of market to let go. We will
see many variations of them in the future."
Update: The US Government has recently enacted law prohibiting
the sale of prehormones supplements.
Myostatin Suppression Supplement
Do you know anything or have
any research about this supplement that supposedly suppresses
myostatin?
Joshua Seedman
replies:
The general consensus seems to be that myostatin expression
in the body is so genetic that no form of supplementation currently
available can alter the genetic state. There are specific companies
out there that are trying to market myostatin inhibitors and
blockers but so far there seems to be no real evidence to prove
that they work. It's kind of funny because as soon as studies
came out about Myostatin and how there was a lack of this gene
in certain animals like the Belgian Blue Cow and certain whippet
dogs everyone started jumping on the bandwagon thinking that
a supplement could easily be made to replicate the same effects
as in these rare creatures. It also appears that there were a
few children born within the last several years who have the
genetic makeup lacking the myostatin gene. It sounds like even
at an early age they are already very muscular and have extreme
potential for muscle growth. There is also a theory out there
that certain bodybuilders such as Ronnie Coleman have this specific
gene as well.
However, there is a certain company called Wyeth that has been
working on Myostatin inhibitors and blockers since the late 90s.
They had been specifically working on a drug called MYO-029 that
had high hopes of blocking myostatin in certain patients with
muscular dystrophy. They also thought that if it worked on patients
with this disease it could possibly transfer into the athletic
setting. However, in the beginning of 2008 they called it quits
on this specific drug due to the fact that studies were not showing
any results from its use. I guess they are still working on blocking
myostatin or limiting its expression but they are starting from
scratch with a new formula.
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