Angiotensin II Receptor Blockers (ARB)

Mechanism of Action

  • Lowers blood pressure by blocking the vasoconstrictor effects of the hormone angiotensin II
  • Angiotensin receptor blockers modulate the renin–angiotensin system

Treatment

  • Hypertension (high blood pressure)
  • Diabetic nephropathy (kidney damage due to diabetes)
  • Congestive heart failure 

Names

  • Azilsartan (Edarbi, Edarbyclor)
  • Candesartan (Amias, Atacand, Blopress, Diceran, Ratacand)
  • Eprosartan (Teveten, Eprozar)
  • Fimasartan (Kanarb)
  • Losartan (Cozaar)
  • Irbesartan (Aprovel, Karvea, and Avapro)
  • Saralasin (Sarenin)
  • Telmisartan (Micardis)
  • Valsartan (Diovan)
  • Olmesartan Medoxomil (Benicar, Olmetec)

Effect on Rest

  • Increase or no change in resting heart rate (ACSM 2013)
  • Decrease in blood pressure (ACSM 2013)

Effect on Exercise

  • Increase or no change in heart rate during exercise (ACSM 2013)
  • Decrease in blood pressure (ACSM 2013)
  • No change in myocardial contractility
  • No change in exercise capacity (ACSM 2013)
  • Increases blood flow and/or decreased vascular resistance during exercise in the myocardium, stomach, small intestine, and colon. (Symons & Stebbins 1996)
  • MAP and SVR during exercise
    • Losartan decreases mean arterial pressure (MAP) and systemic vascular resistance (SVR) during exercise. (Symons & Stebbins 1996)
    • Saralasin, a partial agonist angiotensin II receptor, does not appear to affect mean arterial pressure (MAP) and systemic vascular resistance (SVR) during exercise. (Symons & Stebbins 1996)

References

American College of Sports Medicine (2013). Guidelines for Exercise Testing and Prescription, William & Wilkins, 9, 401

Symons JD, Stebbins CL. (1996). Effects of angiotensin II receptor blockade during exercise: comparison of losartan and saralasin. J Cardiovasc Pharmacol. 28(2):223-31.

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